Khetha Rona
JDK e na le lisebelisoa tsa tlhahiso ea maemo a pele le lisebelisoa tsa taolo ea boleng, tse netefatsang phepelo e tsitsitseng ea li-intermediate tsa API.Sehlopha sa litsebi se tiisetsa R&D ka sehlahisoa.Khahlanong le bobeli, re batla CMO & CDMO 'marakeng oa lapeng le oa machabeng.
Tlhaloso ea Sehlahisoa
Ethyl 2-cyanoacetate ke karolo ea bohlokoa ea ts'ebetso ea tlhahiso ea sethethefatsi sa kalafo se sebetsang hantle haholo sa Finerenone 'me ke karolo ea mantlha ea ho qaptjoa ha sethethefatsi sena se atlehileng.E tsebahala ka katleho ea eona e ikhethang ea ho phekola lefu le sa foleng la liphio le ho hloleha ha pelo, Finerenone e fumane tlhokomelo e atileng ho tsoa ho litsebi tsa bophelo bo botle le bakuli.Ka hona, bohlokoa ba ethyl 2-cyanoacetate bo ke ke ba feteletsoa kaha bo phetha karolo ea bohlokoa tlhahisong ea lithethefatsi tsena tse fetolang bophelo.
Nomoro ea CAS ea ethyl 2-cyanoacetate ke 65193-87-5.E na le mefuta e fapaneng ea lintho tse molemo tse e khethollang ho tse ling tsa meriana.Sebopeho sa eona sa limolek'hule se fana ka botsitso bo babatsehang le ho lumellana le lik'hemik'hale tse sa tšoaneng tsa lik'hemik'hale, ho netefatsa ts'ebetso ea maiketsetso e se nang moeli.Motsoako o boetse o na le bohloeki bo phahameng, o eketsa ho tšepahala le katleho ea oona.
Mehaho ea rona e tsoetseng pele ea tlhahiso le mehato e tiileng ea taolo ea boleng e netefatsa lihlahisoa tsa boleng bo holimo tse fihlelang maemo a thata a indasteri.Sehlopha se seng le se seng sa ethyl 2-cyanoacetate se etsa liteko tse matla ho netefatsa bohloeki ba eona, matla le polokeho.Re utloisisa bohlokoa ba ho fana ka lihlahisoa tse tšepahalang le tse bolokehileng, haholo indastering ea meriana moo bophelo e leng ba bohlokoa.
Ntle le ts'ebetso ea eona e ntle haholo joalo ka finerenone intermediate, ethyl 2-cyanoacetate e fana ka mefuta e mengata lits'ebetsong tse ling.Lintho tsa eona tse ikhethang tsa lik'hemik'hale li etsa hore e be motsoako oa bohlokoa tlhahisong ea metsoako e sa tšoaneng ea meriana le lik'hemik'hale tse ntle.Ethyl 2-cyanoacetate e na le mefuta e mengata ea ts'ebeliso e ka bang teng, e fana ka menyetla e mengata ea boqapi le tsoelo-pele ea k'hemistri ea bongaka.
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