Khetha Rona
JDK e na le lisebelisoa tsa tlhahiso ea maemo a pele le lisebelisoa tsa taolo ea boleng, tse netefatsang phepelo e tsitsitseng ea li-intermediate tsa API.Sehlopha sa litsebi se tiisetsa R&D ka sehlahisoa.Khahlanong le bobeli, re batla CMO & CDMO 'marakeng oa lapeng le oa machabeng.
Tlhaloso ea Sehlahisoa
E entsoe ka hloko ka foromo ea limolek'hule C9H9ClO le boima ba molek'hule ea 168.62, 3-chloropropiophenone ke sehlahisoa sa lik'hemik'hale se fanang ka liphetho tse ntle haholo lits'ebetsong tse fapaneng.Lebitso la eona le leng, 3-chloroacetophenone, e hlalosa ka nepo thepa ea eona ea ts'ebetso e le motsoako oa chlorinated oa acetophenone.Motsoako ona o na le likarolo tse ikhethang tse netefatsang hore ke oa bohlokoa haholo indastering ea meriana le ea lik'hemik'hale.
Khamphani ea rona, re utloisisa bohlokoa ba bohloeki le boleng lihlahisoa tsohle tsa rona.Ke ka lebaka leo 3-chloropropiophenone ea rona e entsoeng ka theknoloji e tsoetseng pele ebile e latela maemo a thata a indasteri.Ka lilemo tsa boitseanape le mehato e tiileng ea taolo ea boleng, re atlehile ho ntlafatsa mekhoa ea rona ea ho kopanya ho netefatsa hore lihlahisoa tsa boleng bo holimo li lula li le teng.
3-chloropropiophenone ea rona e tsejoa ka ho pharaletseng e le ea bohlokoa lipakeng tsa tlhahiso ea dapoxetine, serotonin reuptake inhibitor (SSRI) e khethiloeng e ka rarollang bothata ba ho tsoa pele ho nako.E le karolo e bohareng, 3-chloropropiophenone e phetha karolo ea bohlokoa ho kenyelletsoeng ha dapoxetine 'me ke karolo ea bohlokoa ea sehlahisoa sa ho qetela.
Ho feta moo, 3-chloropropiophenone ea rona, eo hape e tsejoang e le 3-chloroacetophenone, ke motsoako oa bohlokoa o sebelisoang ha ho etsoa lihlahisoa tse ling tse fapaneng tsa meriana le tsa lik'hemik'hale.Ho feto-fetoha ha eona ho fetela ka nģ'ane ho dapoxetine, ho etsa hore e be motsoako oa bohlokoa tlhahisong ea li-antidepressants, li-antiseptics, le lithethefatsi tse ling tse thusang ho ntlafatsa bophelo ba batho.
Tšireletseho ke ea bohlokoa ha u sebetsa le metsoako.Kholiseha hore 3-chloropropiophenone ea rona e etsoa liteko le tlhahlobo e matla ho netefatsa hore e fihlela litekanyetso tse tiileng tsa polokeho.Boitlamo ba rona ho polokeho bo boetse bo atolohela ho sephutheloana sa rona, ho netefatsa hore lihlahisoa tsa rona li fihla li bolokehile ebile li bolokehile monyako oa hau.
